Water → HCID 45095769, compound

HRID 2242498Notes

Reaction equation

HRID 2242498 reaction equation
BrBr.[K+].[Br-:4].[CH2:5]([C:7]1[CH:8]=[CH:9][C:10]([CH:13]=[CH2:14])=[N:11][CH:12]=1)[CH3:6].[OH2:15]>>[Br:4][CH2:14][CH:13]([C:10]1[CH:9]=[CH:8][C:7]([CH2:5][CH3:6])=[CH:12][N:11]=1)[OH:15]

Participants

5

Reactant 4

HCID 962WaterHCID 24408BromineHCID 222462Pyridine, 5-ethyl-2-vinyl-HCID 253877Potassium Bromide

Product 1

HCID 45095769HCID 45095769, compoundYield 86%

Conditions

Temperature
62.5 °C

Procedure

5.5 g (0.0344 mol) liq. Bromine was added to a solution of 7.83 g (0.0658 mol) KBr dissolved in 100 mL water. Reaction mixture was heated to 60-65° C. and 5 g (0.0376 mol) of 5-ethyl-2-vinyl-pyridine was added into it in 10 min. Reaction mixture was stirred for 30 min. and quenched with excess of water. Product was extracted with dichloromethane, which was separated, dried, concentrated and purified to get 7.43 g (86%) of the titled product.

Workup

  1. customReaction mixture
  2. customReaction mixture
  3. customquenched with excess of water
  4. extractionProduct was extracted with dichloromethane, which
  5. customwas separated
  6. customdried
  7. concentrationconcentrated
  8. custompurified

Sources & evidence

ORD record
ord-250f9b8fde8644ee84aed2fbe8a3b2b5
Source dataset
uspto-grants-2010_03
Patent number
US07671207B2

Reaction notes

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