HCID 68546092, compound → HCID 68541729, compound

HRID 2242525Notes

Reaction equation

HRID 2242525 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([O:8]CC2C=CC=CC=2)[CH:5]=[C:4]([Cl:16])[C:3]=1[O:17][CH2:18][CH:19]1[CH2:24][CH2:23][N:22]([C:25]2[CH:30]=[CH:29][C:28]([C:31]([F:34])([F:33])[F:32])=[CH:27][N:26]=2)[CH2:21][CH2:20]1.[H][H]>[Pd].C(OCC)(=O)C.C(O)C>[Cl:16][C:4]1[CH:5]=[C:6]([OH:8])[CH:7]=[C:2]([Cl:1])[C:3]=1[O:17][CH2:18][CH:19]1[CH2:24][CH2:23][N:22]([C:25]2[CH:30]=[CH:29][C:28]([C:31]([F:34])([F:33])[F:32])=[CH:27][N:26]=2)[CH2:21][CH2:20]1

Participants

6

Reactant 2

HCID 68546092HCID 68546092, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 68541729HCID 68541729, compound

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 702EthanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

This compound was prepared in a manner analogous to that of Example 1 Step B, by the treatment of 2.5 grams (0.0049 mole) of 1,3-dichloro-5-(phenylmethoxy)-2-({1-[5-(trifluoromethyl)(2-pyridyl)](4-piperidyl)}methoxy)benzene with hydrogen gas in the presence of 0.3 gram (catalyst) of 10% palladium on carbon in 25 mL of ethyl acetate and 50 mL of ethanol using a Parr hydrogenation apparatus. The yield of the subject compound was 2.0 grams. The NMR spectrum was consistent with the proposed structure.

Workup

  1. customThis compound was prepared in a manner analogous to that of Example 1 Step B

Sources & evidence

ORD record
ord-5d82cfc3232548bca09bf0ba7dbe6899
Source dataset
uspto-grants-2010_03
Patent number
US07671201B2

Reaction notes

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