Methanol → HCID 86737308, compound

HRID 224258Notes

Reaction equation

HRID 224258 reaction equation
C[O:2][C:3](=[O:26])/[CH:4]=[C:5](\[CH3:25])/[CH:6]=[CH:7]/[C:8](/[F:24])=[C:9](\[CH3:23])/[CH:10]=[CH:11]/[C:12]1[C:17]([Cl:18])=[CH:16][C:15]([O:19][CH3:20])=[C:14]([CH3:21])[C:13]=1[Cl:22].CO.[OH-].[Na+].C/C(/C=C/C(/F)=C(\C)/C=C/C1C(Cl)=CC(OC)=C(C)C=1Cl)=C\C(O)=O>O>[CH3:25][C:5]([CH:6]=[CH:7]/[C:8](/[F:24])=[C:9](\[CH3:23])/[CH:10]=[CH:11]/[C:12]1[C:17]([Cl:18])=[CH:16][C:15]([O:19][CH3:20])=[C:14]([CH3:21])[C:13]=1[Cl:22])=[CH:4][C:3]([OH:26])=[O:2]

Participants

6

Reactant 4

HCID 887MethanolHCID 14798Sodium HydroxideHCID 12788565HCID 12788565, compoundHCID 12960821HCID 12960821, compound

Product 1

HCID 86737308HCID 86737308, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

In a manner similar to that described in Example 24, 1.2 g. (3 mmol) of methyl-(2E,4E,6Z,8E)-3,7-dimethyl-6-fluoro-9-(2,6-dichloro-3-methyl-4-methoxyphenyl)-nonatetraenoate were dissolved in 10 ml. of methanol and treated with a solution of 0.59 g. of sodium hydroxide in 4 ml. of water. The work-up as described in Example 24 afforded 2E,4E,6Z,8E-3,7-dimethyl-6-fluoro-9-(2,6-dichloro-3-methyl-4-methoxyphenyl)-2,4,6,8-nonatetraenoic acid.

Sources & evidence

ORD record
ord-c6abc1ee2f054e25bbc41324a2ac04ba
Source dataset
uspto-grants-1980_11
Patent number
US04231944

Reaction notes

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