Ammonia → HCID 59204407, compound

HRID 2242588Notes

Reaction equation

HRID 2242588 reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([C:15]([CH3:21])([CH3:20])/[CH:16]=[CH:17]/[C:18]#[N:19])[CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.N>CO.[Ni]>[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([C:15]([CH3:21])([CH3:20])/[CH:16]=[CH:17]/[CH2:18][NH2:19])[CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 2

HCID 222AmmoniaHCID 59204417HCID 59204417, compound

Product 1

HCID 59204407HCID 59204407, compoundYield 92%

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 887MethanolSolvent

Procedure

Nitrile derivative XXXIV (120 g, 0.43 mol), Raney Ni (30 mL) and ammonia in methanol (750 mL) were placed in a hydrogenator, 15 psi pressure of H2 gas was applied at 60° C. for 12 h. Reaction mass was filtered and the filtrate was concentrated under reduced pressure to give 110 g crude amine XXXV (92%). M+1=282

Workup

  1. customReaction mass
  2. filtrationwas filtered
  3. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-225133bd47d74703bb6b201f505e400f
Source dataset
uspto-grants-2010_03
Patent number
US07671052B2

Reaction notes

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