Trifluoroacetic acid → HCID 87453275, compound

HRID 2242660Notes

Reaction equation

HRID 2242660 reaction equation
C(OC(=O)[NH:7][C@H:8]([C:29]([N:31]1[CH2:35][CH2:34][C@H:33]([F:36])[CH2:32]1)=[O:30])[C@H:9]([CH:11]1[CH2:16][CH2:15][CH:14]([NH:17][C:18]([NH:20][C:21]2[CH:26]=[CH:25][C:24]([F:27])=[CH:23][C:22]=2[F:28])=[O:19])[CH2:13][CH2:12]1)[CH3:10])(C)(C)C.[F:38][C:39]([F:44])([F:43])[C:40]([OH:42])=[O:41]>ClCCl>[F:38][C:39]([F:44])([F:43])[C:40]([O-:42])=[O:41].[F:28][C:22]1[CH:23]=[C:24]([F:27])[CH:25]=[CH:26][C:21]=1[NH:20][C:18]([NH:17][CH:14]1[CH2:15][CH2:16][CH:11]([C@H:9]([CH3:10])[C@H:8]([NH3+:7])[C:29]([N:31]2[CH2:35][CH2:34][C@H:33]([F:36])[CH2:32]2)=[O:30])[CH2:12][CH2:13]1)=[O:19]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 131727926HCID 131727926, compound

Product 1

HCID 87453275HCID 87453275, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of the material prepared in Step C (0.23 g, 0.48 mmol) in dichloromethane (3 mL) was added trifluoroacetic acid (1 mL). After 3 h at ambient temperature the reaction was concentrated in vacuo. Purification by reverse phase HPLC (20%-50% acetonitrile in water) afforded the title compound as a white solid. LC/MS 427.2 (M+H).

Workup

  1. concentrationAfter 3 h at ambient temperature the reaction was concentrated in vacuo
  2. customPurification by reverse phase HPLC (20%-50% acetonitrile in water)

Sources & evidence

ORD record
ord-ed2619b32e344334b5f25e63c88bbf92
Source dataset
uspto-grants-2010_03
Patent number
US07671073B2

Reaction notes

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