HCID 131727928, compound → HCID 86761061, compound

HRID 2242666Notes

Reaction equation

HRID 2242666 reaction equation
[C:1]([O:5][C:6](=[O:34])[NH:7][C@H:8]([C:26]([N:28]1[CH2:32][CH2:31][C@H:30]([F:33])[CH2:29]1)=[O:27])[C@H:9]([CH:11]1[CH2:16][CH2:15][CH:14]([N:17](CC2C=CC=CC=2)[CH3:18])[CH2:13][CH2:12]1)[CH3:10])([CH3:4])([CH3:3])[CH3:2].[H][H]>CO.[OH-].[Pd+2].[OH-]>[F:33][C@H:30]1[CH2:31][CH2:32][N:28]([C:26]([C@@H:8]([NH:7][C:6](=[O:34])[O:5][C:1]([CH3:4])([CH3:3])[CH3:2])[C@H:9]([CH:11]2[CH2:16][CH2:15][CH:14]([NH:17][CH3:18])[CH2:13][CH2:12]2)[CH3:10])=[O:27])[CH2:29]1

Participants

5

Reactant 2

HCID 131727928HCID 131727928, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 86761061HCID 86761061, compound

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 887MethanolSolvent

Procedure

To a solution of the material prepared in Step B (0.18 g, 0.37 mmol) in methanol (100 mL) was added palladium(II) hydroxide (0.10 g). The mixture was placed under 3 atm of hydrogen at ambient temperature for 6 h, then filtered through Celite. The solution was concentrated in vacuo, affording the title compound as a clear oil. This material was used without further purification. LC/MS 386.3 (M+1).

Workup

  1. filtrationfiltered through Celite
  2. concentrationThe solution was concentrated in vacuo

Sources & evidence

ORD record
ord-f97e3b9bb7b346fe92ccc9a92f360f27
Source dataset
uspto-grants-2010_03
Patent number
US07671073B2

Reaction notes

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