Bicarbonate Ion → HCID 23535375, compound

HRID 2242795Notes

Reaction equation

HRID 2242795 reaction equation
[As:1]([C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10]([CH2:12][S:13][CH2:14][CH2:15][C:16]([NH:18][C@H:19]([C:24]([OH:26])=[O:25])[CH2:20][C:21](O)=O)=[O:17])=[O:11])=[CH:5][CH:4]=1)=[O:2].SCCC(N[C@H](C([O-])=O)CC[C:36]([O-:38])=[O:37])=O.[Na+].[Na+].C(=O)(O)[O-].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>CS(C)=O>[As:1]([C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10]([CH2:12][S:13][CH2:14][CH2:15][C:16]([NH:18][C@H:19]([C:24]([OH:26])=[O:25])[CH2:20][CH2:21][C:36]([OH:38])=[O:37])=[O:17])=[O:11])=[CH:5][CH:4]=1)=[O:2]

Participants

6

Reactant 4

HCID 769Bicarbonate IonHCID 11776TriphenylphosphineHCID 23535373HCID 23535373, compoundHCID 86593470HCID 86593470, compound

Product 1

HCID 23535375HCID 23535375, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent3×

Procedure

The procedure used was the same as for N-(3-(4-arsenosophenylcarbamoylmethylthio)-propanoyl)-L-aspartic acid, using 2.63 mL (184 μmol) of 70.0 mM BRAO in DMSO, the disulfide of disodium N-(3-mercaptopropanoyl)-L-glutamate (0.61 g), 0.5 M bicarbonate buffer, pH 9 (10.52 mL, 5.3 mmol), and 0.69 M triphenylphosphine in DMSO (1.7 mL, 1.2 mmol). In this case, DMSO (2 mL) was added to the precipitated mixture before-leaving overnight. The active concentration of trivalent arsenic was found to be 15.4 mM (10.3 mL of solution).

Workup

  1. custombefore-leaving overnight
  2. concentrationThe active concentration of trivalent arsenic

Sources & evidence

ORD record
ord-6bc0bf3939aa4feea0838e2b8b22df36
Source dataset
uspto-grants-2010_03
Patent number
US07674775B2

Reaction notes

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