Bicarbonate Ion → HCID 86593474, compound

HRID 2242796Notes

Reaction equation

HRID 2242796 reaction equation
[As:1]([C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10]([CH2:12]SCCC(N[C@H](C(O)=O)CCC(O)=O)=O)=[O:11])=[CH:5][CH:4]=1)=[O:2].[SH:28][CH2:29][CH2:30][C:31]([NH:33][C@@H:34]1[C@@H:40]([OH:41])[C@H:39]([OH:42])[C@@H:38]([CH2:43][OH:44])[O:37][CH:35]1[OH:36])=[O:32].[Na].[Na].C(=O)(O)[O-].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>CS(C)=O>[As:1]([C:3]1[CH:4]=[CH:5][C:6]([NH:9][C:10]([CH2:12][S:28][CH2:29][CH2:30][C:31]([NH:33][C@@H:34]2[C@@H:40]([OH:41])[C@H:39]([OH:42])[C@@H:38]([CH2:43][OH:44])[O:37][CH:35]2[OH:36])=[O:32])=[O:11])=[CH:7][CH:8]=1)=[O:2]

Participants

6

Reactant 4

HCID 769Bicarbonate IonHCID 11776TriphenylphosphineHCID 23535375HCID 23535375, compoundHCID 86593475HCID 86593475, compound

Product 1

HCID 86593474HCID 86593474, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent2×

Procedure

The procedure used was the same as for N-(3-(4-arsenosophenylcarbamoylmethylthio)propanoyl)-L-glutamic acid, using 3.00 mL (210 μmol) of 70.0 mM BRAO in DMSO, the disulfide of disodium N-(3-mercaptopropanoyl)-D-glucosamine (0.67 g), 0.5 M bicarbonate buffer, pH 9 (11.96 mL, 600 mmol), and 0.69 M triphenylphosphine in DMSO (1.9 mL, 1.3 mmol). The active concentration of trivalent arsenic was found to be 13.5 mM (11.0 mL of solution).

Workup

  1. concentrationThe active concentration of trivalent arsenic

Sources & evidence

ORD record
ord-0bab8fabf1dc4555b66de6342b54db90
Source dataset
uspto-grants-2010_03
Patent number
US07674775B2

Reaction notes

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