Methyl Acrylate → HCID 68707015, compound

HRID 2242860Notes

Reaction equation

HRID 2242860 reaction equation
Cl.[Cl:2][C:3]1[N:4]([C:12]2[CH:22]=[CH:21][C:15]([O:16][CH2:17][CH2:18][NH:19][CH3:20])=[CH:14][CH:13]=2)[N:5]=[C:6]2[C:11]=1[CH:10]=[CH:9][CH:8]=[CH:7]2.[C:23]([O:27][CH3:28])(=[O:26])[CH:24]=[CH2:25]>C(Cl)Cl>[CH3:28][O:27][C:23](=[O:26])[CH2:24][CH2:25][N:19]([CH2:18][CH2:17][O:16][C:15]1[CH:21]=[CH:22][C:12]([N:4]2[C:3]([Cl:2])=[C:11]3[C:6]([CH:7]=[CH:8][CH:9]=[CH:10]3)=[N:5]2)=[CH:13][CH:14]=1)[CH3:20]

Participants

4

Reactant 2

HCID 7294Methyl AcrylateHCID 68704053HCID 68704053, compound

Product 1

HCID 68707015HCID 68707015, compoundYield 95.5%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of the product from step 2 (0.1 g, 0.27 mmol), methyl acrylate (0.15 g, 1.7 mmol) in methylene chloride (2 mL) was stirred at room temperature for 24 h. After the inorganic salts were filtered off, the solvent was removed in vacuo. The crude product was purified by a column chromatography on silica gel eluting with 5% methanol in methylene chloride to afford the ester (100 mg, 60%) MS (APCI) m/z 388 (M+1, 100).

Workup

  1. filtrationAfter the inorganic salts were filtered off
  2. customthe solvent was removed in vacuo
  3. customThe crude product was purified by a column chromatography on silica gel eluting with 5% methanol in methylene chloride

Sources & evidence

ORD record
ord-def84ff61a754826b64c2b290aecf9a7
Source dataset
uspto-grants-2010_03
Patent number
US07674802B2

Reaction notes

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