Sodium Hydroxide → HCID 68707042, compound

HRID 2242864Notes

Reaction equation

HRID 2242864 reaction equation
C[O:2][C:3](=[O:28])[CH2:4][CH2:5][N:6]([CH2:8][CH2:9][CH2:10][O:11][C:12]1[CH:17]=[CH:16][C:15]([N:18]2[C:26]([Cl:27])=[C:25]3[C:20]([CH:21]=[CH:22][CH:23]=[CH:24]3)=[N:19]2)=[CH:14][CH:13]=1)[CH3:7].[OH-].[Na+]>>[ClH:27].[Cl:27][C:26]1[N:18]([C:15]2[CH:14]=[CH:13][C:12]([O:11][CH2:10][CH2:9][CH2:8][N:6]([CH3:7])[CH2:5][CH2:4][C:3]([OH:28])=[O:2])=[CH:17][CH:16]=2)[N:19]=[C:20]2[C:25]=1[CH:24]=[CH:23][CH:22]=[CH:21]2

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 68703839HCID 68703839, compound

Product 1

HCID 68707042HCID 68707042, compoundYield 188.5%

Procedure

The title compound was prepared from product from step 1 (0.2 g, 0.5 mmol) and NaOH (50% in water, 0.080 g, 1.0 mmol) using the procedure of Step 6 of the Example 4 to provide the title compound (0.2 g, 60%). 1H NMR (400 MHz, DMSO) 7.68-7.59 (m, d, J=8.8 Hz, 4H), 7.42-7.38 (m, 1H), 7.24-7.17 (m, d, J=8.8 Hz, 3H), 4.17 (t, J=6 Hz, 2H), 3.27 (m, 4H), 2.77 (m, s, 5H), 2.18 (m, 2H); LC/MS (ESI+) m/z: 99%.

Sources & evidence

ORD record
ord-0da42e9c4c6f44fa9058b91660157062
Source dataset
uspto-grants-2010_03
Patent number
US07674802B2

Reaction notes

Loading…