Ethyl 4-piperidinecarboxylate → HCID 58900147, compound

HRID 2242866Notes

Reaction equation

HRID 2242866 reaction equation
[Cl:1][C:2]1[N:3]([C:11]2[CH:16]=[CH:15][C:14]([O:17][CH2:18][CH2:19][CH2:20]Cl)=[CH:13][CH:12]=2)[N:4]=[C:5]2[C:10]=1[CH:9]=[CH:8][CH:7]=[CH:6]2.[NH:22]1[CH2:32][CH2:31][CH:25]([C:26]([O:28][CH2:29]C)=[O:27])[CH2:24][CH2:23]1>>[Cl:1][C:2]1[N:3]([C:11]2[CH:16]=[CH:15][C:14]([O:17][CH2:18][CH2:19][CH2:20][N:22]3[CH2:32][CH2:31][CH:25]([C:26]([O:28][CH3:29])=[O:27])[CH2:24][CH2:23]3)=[CH:13][CH:12]=2)[N:4]=[C:5]2[C:10]=1[CH:9]=[CH:8][CH:7]=[CH:6]2

Participants

3

Reactant 2

HCID 70770Ethyl 4-piperidinecarboxylateHCID 58900128HCID 58900128, compound

Product 1

HCID 58900147HCID 58900147, compoundYield 81.8%

Procedure

The title compound was prepared 3-chloro-2-[4-(3-chloro-propoxy)-phenyl]-2H-indazole (0.5 g, 1.6 mmol) and ethyl isonipecotate (0.37 g, 2.3 mmol) using the procedure of step 4 of the Example 4 to provide the title compound (0.56 g, 75%) as a hydrochloride salt.

Sources & evidence

ORD record
ord-fed0b8b5c4dc447dbdee44a16720e148
Source dataset
uspto-grants-2010_03
Patent number
US07674802B2

Reaction notes

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