Methyl 4-bromobutyrate → HCID 68704418, compound

HRID 2242875Notes

Reaction equation

HRID 2242875 reaction equation
[Cl:1][C:2]1[N:3]([C:11]2[CH:16]=[CH:15][C:14]([O:17][CH2:18][C@H:19]3[CH2:23][CH2:22][CH2:21][NH:20]3)=[CH:13][CH:12]=2)[N:4]=[C:5]2[C:10]=1[CH:9]=[CH:8][CH:7]=[CH:6]2.Br[CH2:25][CH2:26][CH2:27][C:28]([O:30][CH3:31])=[O:29]>>[CH3:31][O:30][C:28](=[O:29])[CH2:27][CH2:26][CH2:25][N:20]1[CH2:21][CH2:22][CH2:23][C@@H:19]1[CH2:18][O:17][C:14]1[CH:13]=[CH:12][C:11]([N:3]2[C:2]([Cl:1])=[C:10]3[C:5]([CH:6]=[CH:7][CH:8]=[CH:9]3)=[N:4]2)=[CH:16][CH:15]=1

Participants

3

Reactant 2

HCID 107604Methyl 4-bromobutyrateHCID 11587925HCID 11587925, compound

Product 1

HCID 68704418HCID 68704418, compoundYield 80.7%

Procedure

The title compound was prepared from product from 3-chloro-2-[4-((R)-1-pyrrolidin-2-ylmethoxy)-phenyl]-2H-indazole (0.4 g, 1.1 mmol) and methyl 4-bromobutyrate (0.25 g, 1.4 mmol) using the procedure of step 7 of the Example 5 to provide the title compound (0.38 g, 79%).

Sources & evidence

ORD record
ord-ea4b74b4ab204799b9e0af453cdb3ac4
Source dataset
uspto-grants-2010_03
Patent number
US07674802B2

Reaction notes

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