Methyl 4-bromobutyrate → HCID 68708681, compound

HRID 2242877Notes

Reaction equation

HRID 2242877 reaction equation
[Cl:1][C:2]1[N:3]([C:11]2[CH:16]=[CH:15][C:14]([O:17][CH2:18][C@@H:19]3[CH2:23][CH2:22][CH2:21][NH:20]3)=[CH:13][CH:12]=2)[N:4]=[C:5]2[C:10]=1[CH:9]=[CH:8][CH:7]=[CH:6]2.Br[CH2:25][CH2:26][CH2:27][C:28]([O:30][CH3:31])=[O:29]>>[CH3:31][O:30][C:28](=[O:29])[CH2:27][CH2:26][CH2:25][N:20]1[CH2:21][CH2:22][CH2:23][C@H:19]1[CH2:18][O:17][C:14]1[CH:13]=[CH:12][C:11]([N:3]2[C:2]([Cl:1])=[C:10]3[C:5]([CH:6]=[CH:7][CH:8]=[CH:9]3)=[N:4]2)=[CH:16][CH:15]=1

Participants

3

Reactant 2

HCID 107604Methyl 4-bromobutyrateHCID 58900134HCID 58900134, compound

Product 1

HCID 68708681HCID 68708681, compoundYield 75%

Procedure

The title compound was prepared from product from 3-chloro-2-[4-((S)-1-pyrrolidin-2-ylmethoxy)-phenyl]-2H-indazole (0.33 g, 0.94 mmol) and methyl 4-bromobutyrate (0.25 g, 1.4 mmol) using the procedure of Step 1 of the Example 17 to provide the title compound (0.30 g, 75%).

Sources & evidence

ORD record
ord-7c2a4a254cab49d290a851b3a702565a
Source dataset
uspto-grants-2010_03
Patent number
US07674802B2

Reaction notes

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