Hydrochloric Acid → HCID 68543476, compound

HRID 2242899Notes

Reaction equation

HRID 2242899 reaction equation
[NH2:1][C:2]1[C:3]2[N:4]([N:12]=[C:13]([C:15]3[O:16][CH:17]=[CH:18][CH:19]=3)[N:14]=2)[CH:5]=[C:6]([S:8]C(=N)N)[N:7]=1.[OH-].[K+].Cl>>[NH2:1][C:2]1[C:3]2[N:4]([N:12]=[C:13]([C:15]3[O:16][CH:17]=[CH:18][CH:19]=3)[N:14]=2)[CH:5]=[C:6]([SH:8])[N:7]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 685427882-(8-Amino-2-furan-2-yl-[1,2,4]triazolo[1,5-a]pyrazin-6-yl)-isothiourea

Product 1

HCID 68543476HCID 68543476, compound

Procedure

A solution containing the crude 2-(8-amino-2-furan-2-yl-[1,2,4]triazolo[1,5-a]pyrazin-6-yl)-isothiourea and aqueous KOH (1 M, 4 ml) was refluxed for 1 hour. The reaction was neutralized with conc. HCl and the water was removed in vacuo to afford the crude product 8-amino-2-furan-2-yl-[1,2,4]triazolo[1,5-a]pyrazine-6-thiol, which was used in the next step without purification.

Workup

  1. temperaturewas refluxed for 1 hour
  2. customthe water was removed in vacuo

Sources & evidence

ORD record
ord-743e5e122215454a815515e9f839eb1e
Source dataset
uspto-grants-2010_03
Patent number
US07674791B2

Reaction notes

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