反应详情

A solution containing the crude 2-(8-amino-2-furan-2-yl-[1,2,4]triazolo[1,5-a]pyrazin-6-yl)-isothiourea and aqueous KOH (1 M, 4 ml) was refluxed for 1 hour. The reaction was neutralized with conc. HCl and the water was removed in vacuo to afford the crude product 8-amino-2-furan-2-yl-[1,2,4]triazolo[1,5-a]pyrazine-6-thiol, which was used in the next step without purification.

1. temperaturewas refluxed for 1 hour
2. customthe water was removed in vacuo