Trifluoroacetic acid → HCID 11817648, compound

Participants

Reaction Steps

To a solution of [3-(8-amino-2-furan-2-yl-[1,2,4]triazolo[1,5-a]pyrazin-6-yl)-prop-2-ynyl]-carbamic acid tert-butyl ester (100 mg, 0.28 mmol; see Ex. 41 below which was prepared according to Example 3 above) in CH2Cl2 (3 mL) was added trifluoroacetic acid (107 uL, 1.4 mmol). The reaction was stirred at room temperature for 2 hours. The solvent and trifluoroacetic acid was removed to yield 6-(3-amino-prop-1-ynyl)-2-furan-2-yl-[1,2,4]triazolo[1,5-a]pyrazin-8-ylamine as brown oil. The compound was used without further purification. MS: m/z=255 amu (M++H)

Provenance & Evidence