Trifluoroacetic acid → HCID 11817648, compound

HRID 2242917Notes

Reaction equation

HRID 2242917 reaction equation
C(OC(=O)[NH:7][CH2:8][C:9]#[C:10][C:11]1[N:12]=[C:13]([NH2:25])[C:14]2[N:15]([N:17]=[C:18]([C:20]3[O:21][CH:22]=[CH:23][CH:24]=3)[N:19]=2)[CH:16]=1)(C)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl>[NH2:7][CH2:8][C:9]#[C:10][C:11]1[N:12]=[C:13]([NH2:25])[C:14]2[N:15]([N:17]=[C:18]([C:20]3[O:21][CH:22]=[CH:23][CH:24]=3)[N:19]=2)[CH:16]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 11485006HCID 11485006, compound

Product 1

HCID 11817648HCID 11817648, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of [3-(8-amino-2-furan-2-yl-[1,2,4]triazolo[1,5-a]pyrazin-6-yl)-prop-2-ynyl]-carbamic acid tert-butyl ester (100 mg, 0.28 mmol; see Ex. 41 below which was prepared according to Example 3 above) in CH2Cl2 (3 mL) was added trifluoroacetic acid (107 uL, 1.4 mmol). The reaction was stirred at room temperature for 2 hours. The solvent and trifluoroacetic acid was removed to yield 6-(3-amino-prop-1-ynyl)-2-furan-2-yl-[1,2,4]triazolo[1,5-a]pyrazin-8-ylamine as brown oil. The compound was used without further purification. MS: m/z=255 amu (M++H)

Workup

  1. customThe solvent and trifluoroacetic acid was removed

Sources & evidence

ORD record
ord-6bbb0e8930874cd5a179c6b77874b892
Source dataset
uspto-grants-2010_03
Patent number
US07674791B2

Reaction notes

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