Methyl iodide → 1-(m-Chlorophenyl)-3-methyl-3-azabicyclo[3.1.0]hexane hydrochloride

HRID 224296Notes

Reaction equation

HRID 224296 reaction equation
Cl.[Cl:2][C:3]1[CH:4]=[C:5]([C:9]23[CH2:14][CH:13]2[CH2:12][NH:11][CH2:10]3)[CH:6]=[CH:7][CH:8]=1.[CH3:15]I>>[ClH:2].[Cl:2][C:3]1[CH:4]=[C:5]([C:9]23[CH2:14][CH:13]2[CH2:12][N:11]([CH3:15])[CH2:10]3)[CH:6]=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 127198451-(3-Chlorophenyl)-3-azabicyclo[3.1.0]hexane Hydrochloride

Product 1

HCID 128913621-(m-Chlorophenyl)-3-methyl-3-azabicyclo[3.1.0]hexane hydrochloride

Procedure

By the method of Example 10, 1-(m-chlorophenyl)-N-methyl-1,2-cyclopropanedicarboximide, m.p. 72°-73° C., prepared from 1-(m-chlorophenyl)-1,2-cyclopropanedicarboximide (Example 6) and methyl iodide gives 1-(m-chlorophenyl)-3-methyl-3-azabicyclo[3.1.0]hexane hydrochloride as colorless crystals, m.p. 180°-182° C.

Sources & evidence

ORD record
ord-d5f7ffabf2054bcd806513ddadf8c3f0
Source dataset
uspto-grants-1980_11
Patent number
US04231935

Reaction notes

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