1,1-Dimethylethyl 4-[(2,6-dichloro-4-pyrimidinyl)amino]-1-piperidinecarboxylate → HCID 86618542, compound

HRID 2242969Notes

Reaction equation

HRID 2242969 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]2[CH:20]=[C:19]([Cl:21])[N:18]=[C:17]([Cl:22])[N:16]=2)[CH2:10][CH2:9]1)=O)(C)(C)C>C(O)C.Cl.O1CCOCC1>[ClH:21].[ClH:21].[Cl:22][C:17]1[N:16]=[C:15]([NH:14][CH:11]2[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)[CH:20]=[C:19]([Cl:21])[N:18]=1

Participants

5

Reactant 1

HCID 866185411,1-Dimethylethyl 4-[(2,6-dichloro-4-pyrimidinyl)amino]-1-piperidinecarboxylate

Product 1

HCID 86618542HCID 86618542, compound

Reagents, catalysts & solvents 3

HCID 313Hydrochloric AcidSolventHCID 702EthanolSolventHCID 312751,4-DioxaneSolvent

Procedure

A solution of 4-(2,6-dichloro-pyrimidin-4-ylamino)-piperidine-1-carboxylic acid tert-butyl ester (3.1 g, 8.93 mmol) in ethanol (40 mL) and 4 M HCl in dioxane (70 mL) was stirred at rt for 2 h. The solvent was removed under reduced pressure and the crude product used in the consecutive step without further purification assuming quantitative deprotection and formation of the dihydrochloride salt. MS (ISP): 247.3 [M+H]+.

Workup

  1. customThe solvent was removed under reduced pressure
  2. customthe crude product used in the consecutive step without further purification

Sources & evidence

ORD record
ord-7a094e3c1c8d4e99bddad8e124611ed1
Source dataset
uspto-grants-2010_03
Patent number
US07674804B2

Reaction notes

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