HCID 86618543, compound → HCID 86618544, compound

HRID 2242973Notes

Reaction equation

HRID 2242973 reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:10]=[C:9]([NH:11][CH:12]2[CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14][CH2:13]2)[N:8]=[C:7]([Cl:25])[N:6]=1)=[O:4]>C(O)C.Cl.O1CCOCC1>[ClH:25].[ClH:25].[CH3:1][O:2][C:3]([C:5]1[CH:10]=[C:9]([NH:11][CH:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)[N:8]=[C:7]([Cl:25])[N:6]=1)=[O:4]

Participants

5

Reactant 1

HCID 86618543HCID 86618543, compound

Product 1

HCID 86618544HCID 86618544, compound

Reagents, catalysts & solvents 3

HCID 313Hydrochloric AcidSolventHCID 702EthanolSolventHCID 312751,4-DioxaneSolvent

Procedure

A solution of 6-(1-tert-butoxycarbonyl-piperidin-4-ylamino)-2-chloro-pyrimidine-4-carboxylic acid methyl ester (3.46 g, 9.34 mmol) in ethanol (50 mL) and 4 M HCl in dioxane (75 mL) was stirred at rt for 2 h. The solvent was removed under reduced pressure and the crude product used in the consecutive step without further purification assuming quantitative deprotection and formation of the dihydrochloride salt. MS (ISP): 271.1 [M+H]+.

Workup

  1. customThe solvent was removed under reduced pressure
  2. customthe crude product used in the consecutive step without further purification

Sources & evidence

ORD record
ord-695b447733794cecac7d5572f0dcb209
Source dataset
uspto-grants-2010_03
Patent number
US07674804B2

Reaction notes

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