HCID 86618552, compound → HCID 86618553, compound

HRID 2242983Notes

Reaction equation

HRID 2242983 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]2[C:20]([CH2:21][C:22]([O:24][CH2:25][CH3:26])=[O:23])=[C:19]([Cl:27])[N:18]=[C:17]([Cl:28])[N:16]=2)[CH2:10][CH2:9]1)=O)(C)(C)C>ClCCl.Cl.O1CCOCC1>[ClH:27].[ClH:27].[CH2:25]([O:24][C:22](=[O:23])[CH2:21][C:20]1[C:19]([Cl:27])=[N:18][C:17]([Cl:28])=[N:16][C:15]=1[NH:14][CH:11]1[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1)[CH3:26]

Participants

5

Reactant 1

HCID 86618552HCID 86618552, compound

Product 1

HCID 86618553HCID 86618553, compound

Reagents, catalysts & solvents 3

HCID 313Hydrochloric AcidSolventHCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

A solution of 4-(2,6-dichloro-5-ethoxycarbonylmethyl-pyrimidin-4-ylamino)-piperidine-1-carboxylic acid tert-butyl ester (0.87 g, 2.01 mmol) in dichloromethane (10 mL) and 4 M HCl in dioxane (40 mL) was stirred at rt for 2 h. The solvent was removed under reduced pressure and the crude product used in the consecutive step without further purification assuming quantitative deprotection and formation of the dihydrochloride salt. MS (ISP): 333.1 [M+H]+.

Workup

  1. customThe solvent was removed under reduced pressure
  2. customthe crude product used in the consecutive step without further purification

Sources & evidence

ORD record
ord-2b0f292140c54adb854e3eaf99af79ff
Source dataset
uspto-grants-2010_03
Patent number
US07674804B2

Reaction notes

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