反应详情

Using the method of M. Takeda, et al., Chem. Pharm. Bull., 24, 2312 (1976), 1-(p-tolyl)-3-azabicyclo[3.1.0]hexan-2-one is reacted with methyllithium followed by sodium borohydride. Excess reagents are decomposed with methanol, followed by 1 N hydrochloric acid, and then 1 N sodium hydroxide and then evaporation of the solution gives a residue which is dissolved in ether. This solution is dried over sodium sulfate and filtered, and to the filtrate is added dry hydrogen chloride. Filtration of this suspension gives 2-methyl-1-(p-tolyl)-3-azabicyclo[3.1.0]hexane hydrochloride.

1. custom1 N sodium hydroxide and then evaporation of the solution
2. customgives a residue which
3. dry with materialThis solution is dried over sodium sulfate
4. filtrationfiltered
5. additionto the filtrate is added dry hydrogen chloride
6. filtrationFiltration of this suspension