Ethyl isocyanate → HCID 43520595, compound

HRID 2243041Notes

Reaction equation

HRID 2243041 reaction equation
[CH2:1]([NH:3][C:4]([NH:6][C:7]1[CH:12]=[CH:11][C:10](B2OC(C)(C)C(C)(C)O2)=[CH:9][N:8]=1)=[O:5])[CH3:2].[Br:22]C1N=C(N)C=CC=1.C(N=C=O)C>>[Br:22][C:9]1[N:8]=[C:7]([NH:6][C:4]([NH:3][CH2:1][CH3:2])=[O:5])[CH:12]=[CH:11][CH:10]=1

Participants

4

Reactant 3

HCID 8022Ethyl isocyanateHCID 3008092-Amino-6-bromopyridineHCID 592084346-(3-Ethylureido)pyridine-3-boronic acid pinacol ester

Product 1

HCID 43520595HCID 43520595, compound

Procedure

The title compound was synthesized by a method analogous to Intermediate 1 synthesis starting with 6-bromopyridin-2-amine and ethyl isocyanate. The crude residue was purified by flash chromatography (EtOAc/hexanes as eluent). MS (ESP): 245 (M+H+) for C8H10BrN3O; NMR: 1.08 (t, 3H), 3.16 (m, 2H), 7.26 (d, 1H), 7.64 (s, 1H), 7.75 (s, 1H), 8.08 (d, 1H), 9.29 (s, 1H).

Workup

  1. customThe crude residue was purified by flash chromatography (EtOAc/hexanes as eluent)

Sources & evidence

ORD record
ord-cf1e30c5badf4ea3ba3ef05481626e8d
Source dataset
uspto-grants-2010_03
Patent number
US07674801B2

Reaction notes

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