反应详情

温度

70 °C

To a mixture of 5-bromo-2-(3-ethylureido)isonicotinamide (Intermediate 43, 1.25 g, 4.35 mmol) in THF (20 mL), was added Lawessons reagent (1.761 g, 4.35 mmol). The reaction mixture was then heated to 70° C. overnight. The solid that formed was collected by filtration and washed with THF to provide 1 g of desired product. MS (ESP): 304 (M+1) for C19H11BrN4OS

1. customThe solid that formed
2. filtrationwas collected by filtration
3. washwashed with THF