Ammonia → 5-Bromo-2-(3-sec-butylureido)isonicotinamide

HRID 2243067Notes

Reaction equation

HRID 2243067 reaction equation
[Br:1][C:2]1[C:7]([C:8]([NH2:10])=[O:9])=[CH:6][C:5]([NH:11][C:12]([NH:14][CH2:15][CH3:16])=[O:13])=[N:4][CH:3]=1.N[C:18]1[CH:19]=C(C(Br)=CN=1)C(OC)=O.N(C(CC)C)=C=O.N>>[Br:1][C:2]1[C:7]([C:8]([NH2:10])=[O:9])=[CH:6][C:5]([NH:11][C:12]([NH:14][CH:15]([CH2:18][CH3:19])[CH3:16])=[O:13])=[N:4][CH:3]=1

Participants

5

Reactant 4

HCID 222AmmoniaHCID 5508502-IsocyanatobutaneHCID 25307230Methyl 2-amino-5-bromoisonicotinateHCID 59208425AZD7118 Bromo Amide

Product 1

HCID 592083855-Bromo-2-(3-sec-butylureido)isonicotinamide

Procedure

The compound was synthesized by a method analogous to the synthesis of Intermediate 43 starting with methyl 2-amino-5-bromoisonicotinate, 2-isocyanatobutane and ammonia solution (7N, MeOH). MS (ESP): 303 (M+1) for C10H13BrN4O2

Sources & evidence

ORD record
ord-e992a03ed5374c08840641213f6d4ded
Source dataset
uspto-grants-2010_03
Patent number
US07674801B2

Reaction notes

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