HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 5-Bromo-2-(3-sec-butylureido)isonicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 2-Isocyanatobutane | HCID 550850 | — |
| Reactant | Methyl 2-amino-5-bromoisonicotinate | HCID 25307230 | — |
| Reactant | AZD7118 Bromo Amide | HCID 59208425 | — |
| Product | 5-Bromo-2-(3-sec-butylureido)isonicotinamide | HCID 59208385 | — |
Reaction Steps
The compound was synthesized by a method analogous to the synthesis of Intermediate 43 starting with methyl 2-amino-5-bromoisonicotinate, 2-isocyanatobutane and ammonia solution (7N, MeOH). MS (ESP): 303 (M+1) for C10H13BrN4O2
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07674801B2 |
| Source dataset | uspto-grants-2010_03 |
| ORD ID | ord-e992a03ed5374c08840641213f6d4ded |
| Source note | uspto-grants-2010_03 |