反应详情

To a mixture of 5-bromo-2-(3-ethylureido)pyridine-4-carbothioamide (Intermediate 42, 0.146 g, 0.48 mmol) in acetonitrile (3 mL), 2-bromo-1-phenylethanone (0.105 g, 0.53 mmol) was added and the reaction mixture was heated to 80° for 16 h. The reaction mixture was cooled to room temperature and concentrated under reduced pressure. The resulting solids were filtered and washed with acetonitrile to yield 164 mg of the title compound as an off-white solid.

1. additionwas added
2. temperaturethe reaction mixture was heated to 80° for 16 h
3. concentrationconcentrated under reduced pressure
4. filtrationThe resulting solids were filtered
5. washwashed with acetonitrile