Benzoic Acid → HCID 3756095, compound

HRID 2243084Notes

Reaction equation

HRID 2243084 reaction equation
[C:1](O)(=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:10][C:11]1[CH:17]=[C:16]([N+:18]([O-:20])=[O:19])[CH:15]=[CH:14][C:12]=1[S-:13].[Na+].[OH-].[Na+]>O>[C:2]1([C:1]2[S:13][C:12]3[CH:14]=[CH:15][C:16]([N+:18]([O-:20])=[O:19])=[CH:17][C:11]=3[N:10]=2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 243Benzoic AcidHCID 14798Sodium HydroxideHCID 5488199Benzenethiol, 2-amino-4-nitro-, monosodium salt

Product 1

HCID 3756095HCID 3756095, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
117.5 °C

Procedure

PPA (210 g) is added to benzoic acid (12.96 g, 0.104 mol) and sodium 2-amino-4-nitrothiophenoxide (19.98 g, 0.104 mol) (V. L. Guarda, Heterocyclic Comm., 2000, 1.6, 49-54). The mixture is heated at 115-120° C. for 10 minutes, cooled, and water (200 ml) is added dropwise, followed by addition of 32 percent NaOH (pH=5). The product is filtered off and suspended in NaHCO3 ss, filtered off, washed with water and recrystallized from isopropyl ether. Yield: 17.0 g (64%); IR (KBr): 1515, 1341 cm−1; 1H-NMR (d6-DMSO) 8.77 (d, 1H); 8.39 (d, 1H); 8.25 (dd, 1H); 8.11 (dd, 1H); 7.61 (m, 4H).

Workup

  1. temperaturecooled
  2. filtrationThe product is filtered off
  3. filtrationfiltered off
  4. washwashed with water
  5. customrecrystallized from isopropyl ether

Sources & evidence

ORD record
ord-7cedf350f296406dba1184e5ee52b502
Source dataset
uspto-grants-2010_03
Patent number
US07674809B2

Reaction notes

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