HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-{4-[Ethyl(1-methyl-2-oxo-2-phenylethyl)carbamoyl]thiazol-2-yl}piperidinium chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | tert-Butyl 4-{4-[ethyl(1-methyl-2-oxo-2-phenylethyl)carbamoyl]thiazol-2-yl}-piperidine-1-carboxylate | HCID 3849190 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 4-{4-[Ethyl(1-methyl-2-oxo-2-phenylethyl)carbamoyl]thiazol-2-yl}piperidinium chloride | HCID 68454823 | — |
Reaction Steps
tert-Butyl 4-{4-[ethyl(1-methyl-2-oxo-2-phenylethyl)carbamoyl]thiazol-2-yl}-piperidine-1-carboxylate (5.5 mmol; 2.59 g) is dissolved in 13.75 ml of a 4M solution of hydrochloric acid in dioxane. The reaction medium is stirred at room temperature overnight and is then evaporated to dryness to give 2.24 g of a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07674803B2 |
| Source dataset | uspto-grants-2010_03 |
| ORD ID | ord-3f84a86b89e84de79425d311049b46d1 |
| Source note | uspto-grants-2010_03 |