Hydrochloric Acid → 4-{4-[Ethyl(1-methyl-2-oxo-2-phenylethyl)carbamoyl]thiazol-2-yl}piperidinium chloride

HRID 2243107Notes

Reaction equation

HRID 2243107 reaction equation
[CH2:1]([N:3]([CH:24]([CH3:33])[C:25](=[O:32])[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[C:4]([C:6]1[N:7]=[C:8]([CH:11]2[CH2:16][CH2:15][N:14](C(OC(C)(C)C)=O)[CH2:13][CH2:12]2)[S:9][CH:10]=1)=[O:5])[CH3:2].[ClH:34]>O1CCOCC1>[Cl-:34].[CH2:1]([N:3]([CH:24]([CH3:33])[C:25](=[O:32])[C:26]1[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=1)[C:4]([C:6]1[N:7]=[C:8]([CH:11]2[CH2:12][CH2:13][NH2+:14][CH2:15][CH2:16]2)[S:9][CH:10]=1)=[O:5])[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 3849190tert-Butyl 4-{4-[ethyl(1-methyl-2-oxo-2-phenylethyl)carbamoyl]thiazol-2-yl}-piperidine-1-carboxylate

Product 1

HCID 684548234-{4-[Ethyl(1-methyl-2-oxo-2-phenylethyl)carbamoyl]thiazol-2-yl}piperidinium chloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

tert-Butyl 4-{4-[ethyl(1-methyl-2-oxo-2-phenylethyl)carbamoyl]thiazol-2-yl}-piperidine-1-carboxylate (5.5 mmol; 2.59 g) is dissolved in 13.75 ml of a 4M solution of hydrochloric acid in dioxane. The reaction medium is stirred at room temperature overnight and is then evaporated to dryness to give 2.24 g of a white solid.

Workup

  1. customis then evaporated to dryness

Sources & evidence

ORD record
ord-3f84a86b89e84de79425d311049b46d1
Source dataset
uspto-grants-2010_03
Patent number
US07674803B2

Reaction notes

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