HCID 86600004, compound → HCID 68593512, compound

HRID 2243129Notes

Reaction equation

HRID 2243129 reaction equation
[N:1]([CH:4]([C:10]1[N:14]([C:15]2[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=2)[N:13]=[CH:12][CH:11]=1)[CH:5]([CH2:8][CH3:9])[CH2:6][CH3:7])=[N+]=[N-]>CO.[Pd]>[CH2:8]([CH:5]([CH2:6][CH3:7])[CH:4]([NH2:1])[C:10]1[N:14]([C:15]2[CH:16]=[CH:17][C:18]([O:21][CH3:22])=[CH:19][CH:20]=2)[N:13]=[CH:12][CH:11]=1)[CH3:9]

Participants

4

Reactant 1

HCID 86600004HCID 86600004, compound

Product 1

HCID 68593512HCID 68593512, compoundYield 97%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of 5% Pd/C (300 mg) and 5-(1-azido-2-ethylbutyl)-1-(4-methoxyphenyl)-1H-pyrazole (882 mg, 2.95 mmol) in methanol (30 mL) was shaken on a Parr apparatus under 3 atm of H2 for 18 h. The reaction was filtered through a plug of Celite, washed well with methanol and concentrated in vacuo to yield the amine in 97% yield as an oil.

Workup

  1. filtrationThe reaction was filtered through a plug of Celite
  2. washwashed well with methanol
  3. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-c1470c6c86cf4ffba385646cee3dfbba
Source dataset
uspto-grants-2010_03
Patent number
US07674813B2

Reaction notes

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