Hydrochloric Acid → HCID 68508010, compound

HRID 2243205Notes

Reaction equation

HRID 2243205 reaction equation
[OH-].[Na+].C([O:5][C:6](=[O:29])[CH2:7][N:8]1[CH2:12][C:11]([CH3:14])([CH3:13])[CH:10]([O:15][C:16]2[CH:21]=[CH:20][C:19]([C:22]#[N:23])=[C:18]([C:24]([F:27])([F:26])[F:25])[CH:17]=2)[C:9]1=[O:28])C.Cl>C(O)C.O>[C:22]([C:19]1[CH:20]=[CH:21][C:16]([O:15][CH:10]2[C:11]([CH3:14])([CH3:13])[CH2:12][N:8]([CH2:7][C:6]([OH:29])=[O:5])[C:9]2=[O:28])=[CH:17][C:18]=1[C:24]([F:27])([F:26])[F:25])#[N:23]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 56680440HCID 56680440, compound

Product 1

HCID 68508010HCID 68508010, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

Sodium hydroxide (50% in water, 10 mL) was added to a stirring solution of [3-(4-cyano-3-trifluoromethyl-phenoxy)-4,4-dimethyl-2-oxo-pyrrolidin-1-yl]-acetic acid ethyl ester (3) (16.8 mmoles) in ethanol (50 mL) and water (40 mL). The reaction was stirred at ambient temperature overnight. The pH of reaction mixture was adjusted to 2.0 by adding hydrochloric acid (37% in water). The reaction mixture was concentrated in vacuo to remove the ethanol. The desired product (3′) that precipitated from the residue was filtered and dried in a vacuum oven overnight.

Workup

  1. customThe pH of reaction mixture
  2. concentrationThe reaction mixture was concentrated in vacuo
  3. customto remove the ethanol
  4. customThe desired product (3′) that precipitated from the residue
  5. filtrationwas filtered
  6. customdried in a vacuum oven overnight

Sources & evidence

ORD record
ord-f4a2924200c54b12800544ac89dcdddc
Source dataset
uspto-grants-2010_03
Patent number
US07674819B2

Reaction notes

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