(4-Fluoro-3-phenoxyphenyl)methanol → Valine, N-[4-(trifluoromethyl)phenyl]-

HRID 224321Notes

Reaction equation

HRID 224321 reaction equation
[F:1][C:2]([F:20])([F:19])[C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH:13]([CH:14]([CH3:16])[CH3:15])[C:12](=[O:17])[O:11]C2=O)=[CH:5][CH:4]=1.FC1C=CC(CO)=CC=1OC1C=CC=CC=1>>[F:1][C:2]([F:19])([F:20])[C:3]1[CH:8]=[CH:7][C:6]([NH:9][C@H:13]([C:12]([OH:17])=[O:11])[CH:14]([CH3:16])[CH3:15])=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 12874224(4-Fluoro-3-phenoxyphenyl)methanolHCID 204827863-(4-Trifluoromethylphenyl)-4-isopropyloxazolidine-2,5-dione

Product 1

HCID 13388454Valine, N-[4-(trifluoromethyl)phenyl]-

Procedure

In the same way, 3-(4-trifluoromethylphenyl)-4-isopropyloxazolidine-2, 5-dione is reacted with 4-fluoro-3-phenoxybenzyl alcohol to give the 4-fluoro-3-phenoxybenzyl ester of N-(4-trifluoromethylphenyl) valine.

Sources & evidence

ORD record
ord-33d7ea2fee0e40289ae3020a5048ae6f
Source dataset
uspto-grants-1980_11
Patent number
US04231953

Reaction notes

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