Hydrazine hydrate (1:1) → HCID 68692078, compound

HRID 2243214Notes

Reaction equation

HRID 2243214 reaction equation
O.[NH2:2][NH2:3].C1([O:10][C:11](=O)[NH:12][C:13]2[CH:18]=[CH:17][C:16]([S:19][C:20]3[CH:25]=[CH:24][CH:23]=[C:22]([C:26]4([C:32]#[N:33])[CH2:31][CH2:30][O:29][CH2:28][CH2:27]4)[CH:21]=3)=[CH:15][CH:14]=2)C=CC=CC=1>O1CCOCC1>[C:32]([C:26]1([C:22]2[CH:21]=[C:20]([S:19][C:16]3[CH:15]=[CH:14][C:13]([NH:12][C:11]([NH:2][NH2:3])=[O:10])=[CH:18][CH:17]=3)[CH:25]=[CH:24][CH:23]=2)[CH2:31][CH2:30][O:29][CH2:28][CH2:27]1)#[N:33]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 131727933HCID 131727933, compound

Product 1

HCID 68692078HCID 68692078, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
110 °C

Procedure

Hydrazine hydrate (99%, 0.44 g, 8.72 mmol) was added to a solution of phenyl(4-{[3-(4-cyanotetrahydro-2H-pyran-4-yl)phenyl]thio}phenyl)carbamate (1.50 g, 3.49 mmol) (example 5) in 1,4-dioxane (10 mL). The reaction mixture was refluxed at 110° C. for about 4 hours. The solvent was evaporated under vacuum and water was added. The white solid so obtained was filtered under vacuum and dried to obtain the title compound. Yield: 1.0 g

Workup

  1. customThe solvent was evaporated under vacuum and water
  2. additionwas added
  3. customThe white solid so obtained
  4. filtrationwas filtered under vacuum
  5. customdried

Sources & evidence

ORD record
ord-47c396a3f71f4c5088836fe3f80eb240
Source dataset
uspto-grants-2010_03
Patent number
US07674811B2

Reaction notes

Loading…