Potassium Hydroxide → HCID 68694478, compound

Participants

Reaction Conditions

Reaction Steps

Solid potassium hydroxide (0.035 g, 0.6333 mmol) was added to a solution of 4-(3-{[4-(4-ethyl-3-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phenyl]thio}phenyl)tetrahydro-2H-pyran-4-carbonitrile (0.070 g, 0.166 mmol) (example 9) in isopropyl alcohol and methanol mixture (3 mL). The reaction mixture was heated at about 90-100° C. for about 12-15 hours. The solvent was evaporated under vacuum and water was added. A white solid separated out, which was filtered and dried under vacuum to afford the title compound. Yield: 0.045 g.

Provenance & Evidence