Potassium Hydroxide → HCID 68694478, compound

HRID 2243216Notes

Reaction equation

HRID 2243216 reaction equation
[OH-:1].[K+].[CH2:3]([N:5]1[C:9](=[O:10])[N:8]([C:11]2[CH:16]=[CH:15][C:14]([S:17][C:18]3[CH:19]=[C:20]([C:24]4([C:30]#[N:31])[CH2:29][CH2:28][O:27][CH2:26][CH2:25]4)[CH:21]=[CH:22][CH:23]=3)=[CH:13][CH:12]=2)[N:7]=[C:6]1[CH3:32])[CH3:4]>C(O)(C)C.CO>[CH2:3]([N:5]1[C:9](=[O:10])[N:8]([C:11]2[CH:16]=[CH:15][C:14]([S:17][C:18]3[CH:19]=[C:20]([C:24]4([C:30]([NH2:31])=[O:1])[CH2:29][CH2:28][O:27][CH2:26][CH2:25]4)[CH:21]=[CH:22][CH:23]=3)=[CH:13][CH:12]=2)[N:7]=[C:6]1[CH3:32])[CH3:4]

Participants

5

Reactant 2

HCID 14797Potassium HydroxideHCID 24772453HCID 24772453, compound

Product 1

HCID 68694478HCID 68694478, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 3776IsopropanolSolvent

Conditions

Temperature
95 °C

Procedure

Solid potassium hydroxide (0.035 g, 0.6333 mmol) was added to a solution of 4-(3-{[4-(4-ethyl-3-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phenyl]thio}phenyl)tetrahydro-2H-pyran-4-carbonitrile (0.070 g, 0.166 mmol) (example 9) in isopropyl alcohol and methanol mixture (3 mL). The reaction mixture was heated at about 90-100° C. for about 12-15 hours. The solvent was evaporated under vacuum and water was added. A white solid separated out, which was filtered and dried under vacuum to afford the title compound. Yield: 0.045 g.

Workup

  1. customThe solvent was evaporated under vacuum and water
  2. additionwas added
  3. customA white solid separated out
  4. filtrationwhich was filtered
  5. customdried under vacuum

Sources & evidence

ORD record
ord-5195abf731854050ba07e6c9d03aad94
Source dataset
uspto-grants-2010_03
Patent number
US07674811B2

Reaction notes

Loading…