Potassium Hydroxide → HCID 136389307, compound

HRID 2243220Notes

Reaction equation

HRID 2243220 reaction equation
[OH-:1].[K+].[CH3:3][C:4]1[NH:8][C:7](=[O:9])[N:6]([C:10]2[CH:15]=[CH:14][C:13]([S:16][C:17]3[CH:18]=[C:19]([C:23]4([C:29](N)=[O:30])[CH2:28][CH2:27][O:26][CH2:25][CH2:24]4)[CH:20]=[CH:21][CH:22]=3)=[CH:12][CH:11]=2)[N:5]=1>CO.O1CCCC1>[CH3:3][C:4]1[NH:8][C:7](=[O:9])[N:6]([C:10]2[CH:15]=[CH:14][C:13]([S:16][C:17]3[CH:18]=[C:19]([C:23]4([C:29]([OH:1])=[O:30])[CH2:24][CH2:25][O:26][CH2:27][CH2:28]4)[CH:20]=[CH:21][CH:22]=3)=[CH:12][CH:11]=2)[N:5]=1

Participants

5

Reactant 2

HCID 14797Potassium HydroxideHCID 135823070HCID 135823070, compound

Product 1

HCID 136389307HCID 136389307, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

Potassium hydroxide (3.0 mmol) is added to a solution of 4-(3-{[4-(3-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phenyl]thio}phenyl)tetrahydro-2H-pyran-4-carboxamide (1.0 mmol) (example 10) in methanol and tetrahydrofuran (1:2) and the reaction mixture is refluxed for about 18 hours. The solvent is evaporated under vacuum. A small amount of water and concentrated hydrochloric acid are added to the residue to separate out the title compound.

Workup

  1. temperaturethe reaction mixture is refluxed for about 18 hours
  2. customThe solvent is evaporated under vacuum
  3. additionA small amount of water and concentrated hydrochloric acid are added to the residue
  4. customto separate out the title compound

Sources & evidence

ORD record
ord-f0dd0e73c5f844fcaa2efc0b8aa87973
Source dataset
uspto-grants-2010_03
Patent number
US07674811B2

Reaction notes

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