反应详情

(3-Methyl-4-nitrophenyl)-hydrazine (3.0 g) and hexafluoroacetylacetone (3.7 g) were dissolved in toluene and the solution was refluxed for 6 hours. After cooling, the solvent was distilled off and the obtained residue was purified by silica gel column chromatography to obtain 1-(3-methyl-4-nitrophenyl)-3,5-bis(trifluoromethyl)-1H-pyrazole (5.6 g). nD20 1.4890.

1. temperaturethe solution was refluxed for 6 hours
2. temperatureAfter cooling
3. distillationthe solvent was distilled off
4. customthe obtained residue was purified by silica gel column chromatography