HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hexafluoroacetylacetone → 1-(3-Methyl-4-nitrophenyl)-3,5-bis(trifluoromethyl)-1h-pyrazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hexafluoroacetylacetone | HCID 73706 | — |
| Reactant | (3-Methyl-4-nitrophenyl)hydrazine | HCID 13158578 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 1-(3-Methyl-4-nitrophenyl)-3,5-bis(trifluoromethyl)-1h-pyrazole | HCID 59210393 | 92.8% |
Reaction Steps
(3-Methyl-4-nitrophenyl)-hydrazine (3.0 g) and hexafluoroacetylacetone (3.7 g) were dissolved in toluene and the solution was refluxed for 6 hours. After cooling, the solvent was distilled off and the obtained residue was purified by silica gel column chromatography to obtain 1-(3-methyl-4-nitrophenyl)-3,5-bis(trifluoromethyl)-1H-pyrazole (5.6 g). nD20 1.4890.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07674807B2 |
| Source dataset | uspto-grants-2010_03 |
| ORD ID | ord-323fff32557c4e179db5b041f1679146 |
| Source note | uspto-grants-2010_03 |