HCID 68706511, compound → HCID 17958604, compound

HRID 2243300Notes

Reaction equation

HRID 2243300 reaction equation
[C:1]([C:4]1[CH:34]=[CH:33][C:7]([CH2:8][CH:9]([CH:17]=[CH:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=2[O:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH3:32])[CH2:10][CH2:11][CH2:12][CH2:13][C:14]([OH:16])=[O:15])=[CH:6][CH:5]=1)([OH:3])=[O:2].[H][H]>[Pd].C(OCC)(=O)C>[C:1]([C:4]1[CH:5]=[CH:6][C:7]([CH2:8][CH:9]([CH2:17][CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=2[O:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH3:32])[CH2:10][CH2:11][CH2:12][CH2:13][C:14]([OH:16])=[O:15])=[CH:33][CH:34]=1)([OH:3])=[O:2]

Participants

5

Reactant 2

HCID 68706511HCID 68706511, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 17958604HCID 17958604, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

31.6 mg (0.07 mmol) of 6-(4-carboxybenzyl)-8-(2-heptoxyphenyl)-7-octenoic acid from Ex. 25 and 20 mg of palladium/activated carbon (10%) are added to 5 ml of ethyl acetate and, at room temperature and under atmospheric pressure, hydrogenated with hydrogen. After two hours, the mixture is filtered through Celite and concentrated under reduced pressure.

Workup

  1. filtrationthe mixture is filtered through Celite
  2. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-5e565ebbee9145c6a68994e2ce7555ba
Source dataset
uspto-grants-2010_03
Patent number
US07674825B2

Reaction notes

Loading…