HCID 178526310, compound → HCID 178507139, compound

HRID 2243322Notes

Reaction equation

HRID 2243322 reaction equation
[N:1]1[CH:9]=[C:8]2[C:4]([NH:5][C:6]([C:10]3[C:22]4[C:21]5[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=5)[C:15](=[N:23]O)[C:14]=4[CH:13]=[CH:12][CH:11]=3)=[N:7]2)=[N:3][CH:2]=1>C(O)C.O1CCCC1.[Ni]>[N:1]1[CH:9]=[C:8]2[C:4]([NH:5][C:6]([C:10]3[C:22]4[C:21]5[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=5)[CH:15]([NH2:23])[C:14]=4[CH:13]=[CH:12][CH:11]=3)=[N:7]2)=[N:3][CH:2]=1

Participants

5

Reactant 1

HCID 178526310HCID 178526310, compound

Product 1

HCID 178507139HCID 178507139, compoundYield 89.3%

Reagents, catalysts & solvents 3

HCID 935NickelCatalystHCID 702EthanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

The procedure used in Example 6 is followed, in an autoclave, starting from 450 mg of 4-(9H-purin-8-yl)fluoren-9-one oxime (Z,E), obtained in the previous stage, in solution in a mixture of 25 ml of ethanol and 25 ml of tetrahydrofuran, in the presence of Raney activated nickel, under an initial hydrogen pressure of 1 bar, at 600 for 20 hours. After filtration of the catalyst over Celite, and concentration of the filtrate under reduced pressure, in this way, we obtain 384 mg of 4-(9H-purin-8-yl)-9H-fluorene-9(R,S)-amine, in the form of a beige powder with the following characteristics:

Workup

  1. filtrationAfter filtration of the catalyst over Celite, and concentration of the filtrate under reduced pressure

Sources & evidence

ORD record
ord-68e84204ef5c45e8bfee20a30455fd7d
Source dataset
uspto-grants-2010_03
Patent number
US07674795B2

Reaction notes

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