Hydroxyamine hydrochloride → HCID 136360172, compound

HRID 2243337Notes

Reaction equation

HRID 2243337 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:9]=[C:8]([C:10]3[C:22]4[C:21]5[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=5)[C:15](=O)[C:14]=4[CH:13]=[CH:12][CH:11]=3)[NH:7][C:6]=2[CH:24]=1.Cl.[NH2:26][OH:27].C([O-])(=O)C.[Na+]>C(O)C>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:9]=[C:8]([C:10]3[C:22]4[C:21]5[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=5)[C:15](=[N:26][OH:27])[C:14]=4[CH:13]=[CH:12][CH:11]=3)[NH:7][C:6]=2[CH:24]=1

Participants

5

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium AcetateHCID 67360748HCID 67360748, compound

Product 1

HCID 136360172HCID 136360172, compoundYield 99.6%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Stir, at room temperature under argon, a mixture of 1.13 g of 4-(6-bromo-1H-benzimidazol-2-yl)-9H-fluoren-9-one, 0.628 g of hydroxylamine hydrochloride and 1.24 g of sodium acetate in 50 ml of ethanol. The following day, evaporate the reaction medium to dryness under vacuum, take the residue up with 100 ml of water, filter off the solid, and then wash it with 100 ml of water. After drying at 40° C. under vacuum, we obtain 1.17 g of 4-(6-bromo-1H-benzimidazol-2-yl)-9H-fluoren-9-one oxime (Z, E), with the following characteristics:

Workup

  1. customThe following day, evaporate the reaction medium to dryness under vacuum
  2. filtrationfilter off the solid
  3. washwash it with 100 ml of water
  4. customAfter drying at 40° C. under vacuum, we

Sources & evidence

ORD record
ord-9057622f7dd0416faaf20d45b1b52fa6
Source dataset
uspto-grants-2010_03
Patent number
US07674795B2

Reaction notes

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