Potassium Bicarbonate → Acetamide, 2-(3,4-dimethoxyphenyl)-N-(2-(5-methoxyindan-6-yl)ethyl)-

HRID 224334Notes

Reaction equation

HRID 224334 reaction equation
[NH2:1][CH2:2][CH2:3][C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[CH2:9][CH2:8][CH2:7]2.[CH3:15][O:16][C:17]1[CH:18]=[C:19]([CH2:25][C:26](Cl)=[O:27])[CH:20]=[CH:21][C:22]=1[O:23][CH3:24].C(=O)(O)[O-].[K+]>>[CH3:15][O:16][C:17]1[CH:18]=[C:19]([CH2:25][C:26]([NH:1][CH2:2][CH2:3][C:4]2[CH:5]=[C:6]3[C:10](=[CH:11][C:12]=2[O:13][CH3:14])[CH2:9][CH2:8][CH2:7]3)=[O:27])[CH:20]=[CH:21][C:22]=1[O:23][CH3:24]

Participants

4

Reactant 3

HCID 516893Potassium BicarbonateHCID 3604458(3,4-Dimethoxyphenyl)acetyl chlorideHCID 12426123HCID 12426123, compound

Product 1

HCID 3051194Acetamide, 2-(3,4-dimethoxyphenyl)-N-(2-(5-methoxyindan-6-yl)ethyl)-

Procedure

5-Aminoethyl-6-methoxyindan and 3,4-dimethoxyphenylacetyl chloride were reacted following the procedure of Example 1, except that potassium bicarbonate was used in place of triethylamine, to produce the desired product. After recrystallization from ethanol it melted at 115° C.

Sources & evidence

ORD record
ord-cc218c9b27d043f488071459b576483d
Source dataset
uspto-grants-1980_11
Patent number
US04232014

Reaction notes

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