1-Tert-butyl 4-chloromethyl piperidine-1,4-dicarboxylate → 4-Piperidinecarboxylic acid

HRID 2243445Notes

Reaction equation

HRID 2243445 reaction equation
ClC1C=C(C=CC=1NC(=O)CC1CCCC1)C(NC1SC=CN=1)=O.ClC[O:27][C:28]([CH:30]1[CH2:35][CH2:34][N:33](C(OC(C)(C)C)=O)[CH2:32][CH2:31]1)=[O:29]>>[NH:33]1[CH2:34][CH2:35][CH:30]([C:28]([OH:29])=[O:27])[CH2:31][CH2:32]1

Participants

3

Reactant 2

HCID 101075661-Tert-butyl 4-chloromethyl piperidine-1,4-dicarboxylateHCID 16122817HCID 16122817, compound

Product 1

HCID 37734-Piperidinecarboxylic acid

Procedure

Prepared from 3-chloro-4-(2-cyclopentyl-acetylamino)-N-thiazol-2-yl-benzamide and piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-chloromethyl ester followed by deprotection.

Sources & evidence

ORD record
ord-f31094c4d411494a8d7c5aa52e5fa3cd
Source dataset
uspto-grants-2010_03
Patent number
US07674912B2

Reaction notes

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