Hydrochloric Acid → HCID 70590744, compound

Participants

Reaction Steps

17-Cyano-3,14-dimethoxy-4,5α-epoxy-8α-methylmorphinan-6-one (3) (6.0 g, 16.9 mmol) was combined with 250 ml of 2N HCl and refluxed under a nitrogen atmosphere for 3 hours. The contents of the reaction flask were concentrated under reduced pressure to give 6.1 g (99% theory) of a brownish solid which was dried and used without further purification.

Provenance & Evidence