Hydrochloric Acid → HCID 70590744, compound

HRID 224354Notes

Reaction equation

HRID 224354 reaction equation
C([N:3]1[CH2:22][CH2:21][C@:10]23[C:11]4[C:12]5[O:20][C@H:9]2[C:8](=[O:23])[CH2:7][C@@H:6]([CH3:24])[C@@:5]3([O:25][CH3:26])[C@H:4]1[CH2:17][C:16]=4[CH:15]=[CH:14][C:13]=5[O:18][CH3:19])#N.[ClH:27]>>[ClH:27].[CH3:19][O:18][C:13]1[CH:14]=[CH:15][C:16]2[CH2:17][C@H:4]3[NH:3][CH2:22][CH2:21][C@:10]45[C:11]=2[C:12]=1[O:20][C@H:9]4[C:8](=[O:23])[CH2:7][C@@H:6]([CH3:24])[C@@:5]35[O:25][CH3:26]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 86737313HCID 86737313, compound

Product 1

HCID 70590744HCID 70590744, compound

Procedure

17-Cyano-3,14-dimethoxy-4,5α-epoxy-8α-methylmorphinan-6-one (3) (6.0 g, 16.9 mmol) was combined with 250 ml of 2N HCl and refluxed under a nitrogen atmosphere for 3 hours. The contents of the reaction flask were concentrated under reduced pressure to give 6.1 g (99% theory) of a brownish solid which was dried and used without further purification.

Workup

  1. temperaturerefluxed under a nitrogen atmosphere for 3 hours
  2. concentrationThe contents of the reaction flask were concentrated under reduced pressure
  3. customto give 6.1 g (99% theory) of a brownish solid which
  4. customwas dried
  5. customused without further purification

Sources & evidence

ORD record
ord-48b44bb267ed4e75ba6afb2d509105f0
Source dataset
uspto-grants-1980_11
Patent number
US04232028

Reaction notes

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