Hydrochloric Acid → HCID 68544108, compound

HRID 2243548Notes

Reaction equation

HRID 2243548 reaction equation
[OH-].[Na+].[OH:3][C@H:4]([C:32]1[CH:37]=[CH:36][C:35]([OH:38])=[CH:34][CH:33]=1)[C@@H:5]([NH:7][CH2:8][CH2:9][O:10][C:11]1[CH:16]=[C:15]([CH3:17])[C:14]([C:18]2[CH:23]=[CH:22][C:21]([O:24][CH2:25][C:26]([O:28]CC)=[O:27])=[CH:20][CH:19]=2)=[C:13]([CH3:31])[CH:12]=1)[CH3:6].O.Cl>O1CCOCC1>[OH:3][C@H:4]([C:32]1[CH:37]=[CH:36][C:35]([OH:38])=[CH:34][CH:33]=1)[C@@H:5]([NH:7][CH2:8][CH2:9][O:10][C:11]1[CH:16]=[C:15]([CH3:17])[C:14]([C:18]2[CH:23]=[CH:22][C:21]([O:24][CH2:25][C:26]([OH:28])=[O:27])=[CH:20][CH:19]=2)=[C:13]([CH3:31])[CH:12]=1)[CH3:6]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 86605509ethyl (4'-(2-[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethylamino]ethoxy}-2',6'-dimethylbiphenyl-4-yloxy)acetate

Product 1

HCID 68544108HCID 68544108, compoundYield 79.5%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A 1 mol/L aqueous solution of sodium hydroxide (0.81 mL) was added to a mixture of ethyl (4′-{2-[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethylamino]ethoxy}-2′,6′-dimethyl biphenyl-4-yloxy)acetate (0.16 g), water (1 mL) and 1,4-dioxane (2 mL), and the mixture was stirred at room temperature overnight. 1 mol/L hydrochloric acid (0.81 mL) was added to the reaction mixture, and the organic solvent was evaporated under reduced pressure. The precipitate was collected by filtration to afford the title compound (0.12 g) as a pale yellow amorphous. The structure and physical data were shown in table 1.

Workup

  1. customthe organic solvent was evaporated under reduced pressure
  2. filtrationThe precipitate was collected by filtration

Sources & evidence

ORD record
ord-1d87409b45744e91b3cbd44a3ef8fd37
Source dataset
uspto-grants-2010_03
Patent number
US07674938B2

Reaction notes

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