反应详情

A 4 mol/L solution of hydrogen chloride in 1,4-dioxane (0.1 mL) was added to a suspension of 4′-{2-[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethylamino]ethoxy}-3′,5′-dimethylbiphenyl-4-carboxylic acid (compound 1, 0.089 g) in 1,4-dioxane (11.0 mL), and the mixture was stirred at room temperature for 30 min. The clear solution was diluted with an excess amount of diethyl ether, and stirred at that temperature for 1 hr. The precipitate was collected by filtration to afford the title compound (0.083 g) as a gray amorphous. The structure and physical data were shown in table 4.

1. stirringstirred at that temperature for 1 hr
2. filtrationThe precipitate was collected by filtration