Hydrogen Bromide → HCID 68547299, compound

HRID 2243558Notes

Reaction equation

HRID 2243558 reaction equation
[OH:1][C@H:2]([C:26]1[CH:31]=[CH:30][C:29]([OH:32])=[CH:28][CH:27]=1)[C@@H:3]([NH:5][CH2:6][CH2:7][O:8][C:9]1[C:14]([CH3:15])=[CH:13][C:12]([C:16]2[CH:21]=[CH:20][C:19]([C:22]([OH:24])=[O:23])=[CH:18][CH:17]=2)=[CH:11][C:10]=1[CH3:25])[CH3:4].[BrH:33]>O1CCOCC1.C(OCC)C>[BrH:33].[OH:1][C@H:2]([C:26]1[CH:31]=[CH:30][C:29]([OH:32])=[CH:28][CH:27]=1)[C@@H:3]([NH:5][CH2:6][CH2:7][O:8][C:9]1[C:14]([CH3:15])=[CH:13][C:12]([C:16]2[CH:21]=[CH:20][C:19]([C:22]([OH:24])=[O:23])=[CH:18][CH:17]=2)=[CH:11][C:10]=1[CH3:25])[CH3:4]

Participants

5

Reactant 2

HCID 260Hydrogen BromideHCID 68540748HCID 68540748, compound2×

Product 1

HCID 68547299HCID 68547299, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 312751,4-DioxaneSolvent

Procedure

To a suspension of 4′-{2-[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethylamino]ethoxy}-3′,5′-dimethyl-biphenyl-4-carboxylic acid (compound 1, 0.079 g) in 1,4-dioxane (0.91 mL) was added 47% hydrobromic acid (0.042 mL), and the mixture was stirred at room temperature for 10 min. The clear solution was diluted with an excess amount of diethyl ether, and the precipitate was collected by filtration to afford the title compound (0.037 g) as a pale brown amorphous. The structure and physical data were shown in table 4.

Workup

  1. filtrationthe precipitate was collected by filtration

Sources & evidence

ORD record
ord-8565e58f93bd440d810c3d018b34d85b
Source dataset
uspto-grants-2010_03
Patent number
US07674938B2

Reaction notes

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