Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | Lithium Chloride | HCID 433294 | — |
| Reactant | 4-(2-(Dimethylamino)ethoxy)benzeneboronic acid, pinacol ester | HCID 42598924 | — |
| Reactant | HCID 178516673 | HCID 178516673 | — |
| Catalyst | HCID 178418807 | HCID 178418807 | — |
| Product | HCID 178483875 | HCID 178483875 | — |
Reaction Steps
The mixture of 5-fluoro-2-iodo-3-phenyl-furo[2,3-b]pyridin-4-ol (5) (90.0 mg, 0.24, mmol), dimethyl-(2-[4-(4,4,5,5-tetramethyl-(1,3,2)dioxaborolan-2-yl)-phenoxy]-ethyl)-amine (114.0 mg, 0.39 mmol), LiCl (33.1 mg, 0.78 mmol), Pd(dppf)2Cl2 DCM (24.5 mg, 0.03 mmol) and Na2CO3 (0.33 mL, 2.0 M in water, 0.65 mmol) was degassed and heated to 80° C. with stirring under nitrogen for 5 h. The solvent was removed. The residue was purified by preparative HPLC to give the title compound. MS (m/z), M+H+ 393.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07674907B2 |
|---|
| Source dataset | uspto-grants-2010_03 |
|---|
| ORD ID | ord-bdb9bd2142a242f9b4905239d432c905 |
|---|
| Source note | uspto-grants-2010_03 |
|---|
