4-Amino-1-Boc-piperidine → HCID 11951868, compound

HRID 2243650Notes

Reaction equation

HRID 2243650 reaction equation
[CH:1]1([CH2:4][NH:5][C:6](=[O:36])[C:7]2[CH:12]=[CH:11][C:10]([CH3:13])=[C:9]([C:14]3[C:23]4[CH2:22][NH:21][C:20](=[O:24])[N:19]([C:25]5[C:30]([F:31])=[CH:29][CH:28]=[CH:27][C:26]=5[F:32])[C:18]=4[N:17]=[C:16](S(C)=O)[N:15]=3)[CH:8]=2)[CH2:3][CH2:2]1.[NH2:37][CH:38]1[CH2:43][CH2:42][N:41]([C:44]([O:46][C:47]([CH3:50])([CH3:49])[CH3:48])=[O:45])[CH2:40][CH2:39]1>C1COCC1>[CH:1]1([CH2:4][NH:5][C:6]([C:7]2[CH:12]=[CH:11][C:10]([CH3:13])=[C:9]([C:14]3[C:23]4[CH2:22][NH:21][C:20](=[O:24])[N:19]([C:25]5[C:30]([F:31])=[CH:29][CH:28]=[CH:27][C:26]=5[F:32])[C:18]=4[N:17]=[C:16]([NH:37][CH:38]4[CH2:39][CH2:40][N:41]([C:44]([O:46][C:47]([CH3:50])([CH3:49])[CH3:48])=[O:45])[CH2:42][CH2:43]4)[N:15]=3)[CH:8]=2)=[O:36])[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 12682914-Amino-1-Boc-piperidineHCID 11949928HCID 11949928, compound

Product 1

HCID 11951868HCID 11951868, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To the solution of N-(Cyclopropylmethyl)-3-[8-(2,6-difluorophenyl)-2-(methylsulfinyl)-7-oxo-5,6,7,8-tetrahydropyrimido[4,5-d]pyrimidin-4-yl]-4-methylbenzamide (100 mg) in THF (10 mL) was added 1,1-dimethylethyl 4-amino-1-piperidinecarboxylate (195 mg) at r.t. The reaction mixture was heated at reflux for 4 h. The solution was then evaporated in vacuo and the residue was purified by column chromatography to provide the title compound as a white solid. LC-MS m/z 648.4 (M+H)+, 2.16 min (ret. time).

Workup

  1. temperatureThe reaction mixture was heated
  2. temperatureat reflux for 4 h
  3. customThe solution was then evaporated in vacuo
  4. customthe residue was purified by column chromatography

Sources & evidence

ORD record
ord-9e03134784d44e1b8b7915c2bfbbc232
Source dataset
uspto-grants-2010_03
Patent number
US07674789B2

Reaction notes

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